Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-09-25
2000-02-01
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 64, 536 185, A61K 3170, C07H 100, C07H 1524
Patent
active
060203161
ABSTRACT:
Clinical utility of chemotherapy agents is limited by dose-dependent systemic toxicity and emergence of resistant tumor cell lines. The present invention provides derivatives of chemotherapeutic agents which can overcome these limitations. Reaction of a parent drug with glutaraldehyde in aqueous solution followed by ethanolamine yields a product which exhibits enhanced antitumor cytotoxicity and overcomes resistance developed against the parent drug. The derivative compounds of the invention achieve therapeutic effects comparable to those of the parent drugs but at much lower doses, thereby reducing undesirable toxic side effects. The most preferred derivative is glutaraldehyde-modified doxorubicin. Most preferred are methods of treatment for subjects suffering from cancer which comprise administration of glutaraldehyde-modified doxorubicin.
REFERENCES:
patent: 4202967 (1980-05-01), Tong et al.
patent: 4460560 (1984-07-01), Tokes et al.
patent: 4625019 (1986-11-01), Relyveld
patent: 5208323 (1993-05-01), Pase et al.
LandOfFree
Glutaraldehyde modified chemotherapeutic agents and methods of u does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glutaraldehyde modified chemotherapeutic agents and methods of u, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glutaraldehyde modified chemotherapeutic agents and methods of u will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-937602