Glutaraldehyde-fixed bioprostheses

Details Glutaraldehyde-fixed bioprostheses Glutaraldehyde-fixed bioprostheses

1998-03-20

1999-08-10

Yu, Mickey

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 1, 623 2, 8 9411, A61F 202

Patent

active

059351683

ABSTRACT:
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate there propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and cross-linked by glutaraldehyde are exposed to a carboxyl activating agent to convert the free carboxyl (COOH) groups of the collagen molecules to activated carboxyl moieties (e.g., o-acylisourea). Thereafter, the collagenous tissue is exposed to a compound capable of reacting with the activated carboxyl moieties (e.g., o-acylisourea) to form non-carboxyl side groups. Monofunctional and multifunctional amines are examples of compounds which may be utilized to react with the activated carboxyl moieties to form such non-carboxyl side groups. Thereafter, the collagenous tissue is again exposed to glutaraldehyde. If the non-carboxyl side groups have functional amino groups (NH.sub.2), such additional exposure to glutaraldehyde will result in additional glutaraldehyde cross-linking of the collagen molecules and resultant improvement of durability.

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