Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-11-14
1996-11-26
Kim, Kay K. A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242361, 42419711, 530403, 530404, 530405, 530406, 530409, 530410, A61K 3910, A61K 39385, C07K 14235, C07K 1700
Patent
active
055783082
ABSTRACT:
A detoxified B. pertussis toxin or antigenic preparation is described, which is characterized by stability to reversion to toxicity upon storage at 4.degree.-8.degree. C. and at temperatures above 23.degree. C. Also provided are methods for producing detoxified pertussis toxin and vaccines containing same.
REFERENCES:
patent: 3983229 (1976-09-01), Relyveld et al.
patent: 4070454 (1978-07-01), Relyveld et al.
patent: 4075321 (1978-05-01), Relyveld et al.
patent: 4788058 (1988-11-01), Parton et al.
patent: 4849358 (1989-07-01), Chazono et al.
patent: 4888169 (1989-12-01), Brown et al.
patent: 4996299 (1991-02-01), Ginnaga et al.
patent: 4997915 (1991-03-01), Tan et al.
R. K. Gupta et al., J. of Biol. Stand. (1987) 15, 159-164.
A. C. Wardlaw et al., J. med. Micro. Bio., (1976) 9, 89-100.
Munoz et al., Infect. Immunity, (1981) 32, 243-250.
Weiss et al., Ann. Rev. Microbiol., 40:661 (1986).
Habeeb (1969) "A Study of the Antigenicity of Formaldehyde-and Glutaraldehyde-Treated Bovine Serum Albumin and Ovalbumin-Bovine Serum Albumin Conjugate" J. Immunol 102(2):457-465.
Habeeb (1987) "Schistosoma Mansoni: Chemical Stabilization of Cercariae by Aldehydes" Exptl. Parasitol. 64:111-119.
Gupta et al (1987) "The Effects of Different Inactivating Agents on the Potency, Toxicity and Stability of Pertussis Vaccine" J. Biol. Stand. 15:87-98.
Andreescu et al (1980) "Comparative Studies of Pertussis Vaccine Batches Inactivated with Glutaraldehyde, .beta.-Propiolactone, Formaldehyde or Thimerosal" Arch. Roum. Path. Exp. Microbiol. 38(3-4):299-308.
Davis et al (1974) "Retention of Significant Antibody Binding by Surface Antigens of Feline Leukemia Cells (FLA) After Fixation with Formaldehyde and Glutaraldehyde" Immunol. Commun. 3(2):189-196.
Kongsvik et al (1974) "Studies on the Red Cell and Antibody-Reactive Sites of the Parvovirus H--1: Effect of Fixatives" Proc. Soc. Exptl. Biol. Med. 145:763-770.
Capiau Carine
Petre Jean
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