Glutaminase inhibitory compounds, compositions, and methods of u

Details Glutaminase inhibitory compounds, compositions, and methods of u Glutaminase inhibitory compounds, compositions, and methods of u

1994-11-21

1996-09-03

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483315, 5483321, 5483325, 5483351, 5483471, C07D23364, C07D23320, A61K 31415

Patent

active

055524273

ABSTRACT:
There is disclosed a pharmaceutical composition for inhibiting glutaminase which comprises a imidazole derivative or a salt thereof. This compound selectively inhibits the proliferation of tumor cells, and the composition is useful as an anti-cancer agent. There is also disclosed a imidazole derivative having glutaminase inhibitory activity.

REFERENCES:
patent: 2742481 (1956-04-01), Cain
patent: 3459763 (1969-08-01), Gruenfeld
patent: 4801602 (1989-01-01), Ahond et al.
Colson et al., "Mode of Action of the Antitumor Compound Girodazole (RP 49532A, NSC 627434)", Biochem. Pharm., vol. 43, No. 8, (1992), pp. 1717-1723.
Cook et al., "Studies on the Toxic Effects of Some Nitrogen-Containing Secondary Plant Compounds on Rat Hepatoma Cells", vol. 14, May 1986, pp. 1053-1054.
Lillie et al., "Cyclocreatine (1-Carboxymethyl-2-iminoimidazolidine) Inhibits Growth of a Broad Spectrum of Cancer Cells Derived from Solid Tumors", Cancer Research, vol. 53, No. 13, Jul. 1993, pp. 2937-3215.
Mulcahy et al., "Enhancement Of Melphalan (L-PAM) Toxicity By Reductive Metabolites Of 1-Methyl-2-Nitroimidazole, A Model Nitroimidazole Chemosensitizing Agent", Biochemical Pharmacology, vol. 40, Nol 12, pp. 2671-2676, (1990).

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