Glutamic acid decarboxylase (GAD) based delivery system

Details Glutamic acid decarboxylase (GAD) based delivery system Glutamic acid decarboxylase (GAD) based delivery system

2011-06-07

2011-06-07

Falk, Anne-Marie (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C435S320100

Reexamination Certificate

active

07955595

ABSTRACT:
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.

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