Glutamate receptor inhibitor

Details Glutamate receptor inhibitor Glutamate receptor inhibitor

1987-06-08

1989-08-08

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

424 95, 514 2, 514 21, 514 17, 514 18, 530344, 530330, 530331, C07K 1500, A61K 3556, A61K 3702

Patent

active

048554057

ABSTRACT:
A novel glutamate receptor inhibitor obtained from Joro spider venom glands, and its manufacturing method.

REFERENCES:
patent: 4452888 (1984-06-01), Yamazaki et al.
Brain Research, 247, 169-171, (1982), Kawai et al.
Central Patents Index, Basic Abstracts Journal Section B, Farmdoc, (1980).
Microelectrophoretic Investigations of Mammalian Central Transmitters (Aug. 25, 1983), Australia, Lecture Summaries, p. 4, Kawai et al.
Congress of the International Union of Physiological Sciences, (Aug. 29, 1983), Australia, Lecture Summaries, p. 89, Kawai et al.
Bochem. and Biophys. Res. Comm., 90, (1979), 1194-1200, Blank et al.
J. of Clinical Science, 17, No. 12, (1981), Masugi et al., (English transation), V-of Record in parent 707, 381.
Mandel et al., Advances in Biochemical Psychopharmacology, (1983), 37, pp. 227-221, "CNS Receptors--From Molecular Pharmacology to Behavior".
Abe et al., J. Physiol., (1983), 339, pp. 243-252, "Effects of a Spider Toxin on the Glutaminergic Synapse of Lobster Muscle".
Kawai et al., Chemical Abstratcs, 97, No. 11, Sep. 13, 1982, p. 255, No. 86723b, Columbus, Ohio, U.S., "Effect of a Spider Toxin on Glutaminergic Synapses in the Mammalian Brain", and Biomed. REs. 1982, 3(3), 53-5, Abstract.
Kawai et al., Brain Research, (1983), 278, pp. 346-349, "Blockade of Squid Giant Synapse by a Spider Toxin".

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