Glutamate receptor compositions and method

Details Glutamate receptor compositions and method Glutamate receptor compositions and method

1995-06-06

1999-08-31

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 536 235, C07K 14705, C12N 1512

Patent

active

059455098

ABSTRACT:
The present invention discloses novel DNAs that encode proteins having electrophysiological and pharmacological properties characteristic of glutamate receptors. The glutamate receptors are exemplified by proteins encoded by representative cDNA clones GluR1, GluR2, GluR3, GluR4, GluR5, GluR6 and GluR7, fragments thereof, and functional combinations of these glutamate receptor proteins and/or fragments. DNA sequences from the cDNA clones for GluR1, GluR2, GluR3, GluR4 and GluR5 are especially useful as probes, thus enabling those skilled in the art to identify, without undue experimentation, other members of the L-glutamate receptor family.

REFERENCES:
Grenningloh et al. Alpha subunit variants of the human glycine receptor: primary structures, functional expression an chromosomal localization of the corresponding genes. The EMBO Journal 9(3):771-776, Mar. 1990.
Schofield et al. Sequence and expression of human GABA-A receptor alpha1 and beta1 subunits. FEBS Letters 244(2):361-364, FEB. 1989.
Huetther et al. P.N.A.S. 85:1307-1311, Feb. 1988.

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