Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-16
2011-08-16
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S616000, C514S469000, C514S355000, C514S438000, C564S153000, C549S462000, C549S029000, C544S336000
Reexamination Certificate
active
07998965
ABSTRACT:
The present invention relates to modulators of metalloproteinase activity.
REFERENCES:
patent: 4769389 (1988-09-01), Makovec et al.
patent: 5563127 (1996-10-01), Amparo et al.
patent: 5597825 (1997-01-01), Himmelsbach et al.
patent: 5602179 (1997-02-01), Makovec et al.
patent: 5618825 (1997-04-01), Baldwin et al.
patent: 5648368 (1997-07-01), Egbertson et al.
patent: 5698538 (1997-12-01), Amparo et al.
patent: 5736559 (1998-04-01), Himmelsbach et al.
patent: 5756810 (1998-05-01), Baldwin et al.
patent: 5852007 (1998-12-01), Chatterjee
patent: 5922763 (1999-07-01), Himmelsbach et al.
patent: 6242422 (2001-06-01), Karanewsky et al.
patent: 6306840 (2001-10-01), Adams et al.
patent: 6376538 (2002-04-01), Adams et al.
patent: 6605608 (2003-08-01), Seko et al.
patent: 6624152 (2003-09-01), Adams et al.
patent: 6630512 (2003-10-01), Adams et al.
patent: 6723711 (2004-04-01), Biediger et al.
patent: 2002/0019416 (2002-02-01), Fukami et al.
patent: 2002/0091089 (2002-07-01), Karanewsky et al.
patent: 2002/0169326 (2002-11-01), Fukami et al.
patent: 2003/0013725 (2003-01-01), Seko et al.
patent: 2003/0018016 (2003-01-01), Adams et al.
patent: 2003/0083267 (2003-05-01), Adams et al.
patent: 2003/0199692 (2003-10-01), Biediger et al.
patent: 2003/0232806 (2003-12-01), Seko et al.
patent: 2004/0009956 (2004-01-01), Pei et al.
patent: 2004/0063959 (2004-04-01), Fukami et al.
patent: 2004/0259804 (2004-12-01), Karanewsky
patent: 2005/0049242 (2005-03-01), Robinson et al.
patent: 3332633 (1985-04-01), None
patent: 496378 (1992-07-01), None
patent: 751765 (1997-01-01), None
patent: 805796 (1997-11-01), None
patent: 854863 (1998-07-01), None
patent: 997147 (2000-05-01), None
patent: 1090912 (2001-04-01), None
patent: 1142867 (2001-10-01), None
patent: 1189881 (2002-03-01), None
patent: 1213288 (2002-06-01), None
patent: 1 108 819 (1968-04-01), None
patent: 2292149 (1996-02-01), None
patent: 06192199 (1994-07-01), None
patent: 11080191 (1999-03-01), None
patent: 11116541 (1999-04-01), None
patent: 2002145849 (2002-05-01), None
patent: WO-94/12181 (1994-06-01), None
patent: WO-95/24186 (1995-09-01), None
patent: WO-96/20689 (1996-07-01), None
patent: WO-96/22966 (1996-08-01), None
patent: WO-97/03951 (1997-02-01), None
patent: WO-97/21690 (1997-06-01), None
patent: WO-99/02146 (1999-01-01), None
patent: WO-99/48371 (1999-09-01), None
patent: WO-00/00470 (2000-01-01), None
patent: WO-00/23421 (2000-04-01), None
patent: WO-00/27808 (2000-05-01), None
patent: WO-00/68188 (2000-11-01), None
patent: WO-01/83445 (2001-11-01), None
patent: WO-01/90077 (2001-11-01), None
patent: WO 03/093498 (2003-11-01), None
patent: WO-2005/019167 (2005-03-01), None
patent: WO-2005/040355 (2005-05-01), None
patent: WO-2005/058808 (2005-06-01), None
patent: WO-2005/060456 (2005-07-01), None
Baker et al., Journal of Pharmaceutical Sciences (1966), 55(3), p. 295-302.
“Poster at the OARSI World Congress on Osteoarthritis 2007 held from Dec. 6-9, 2007 in Fort Lauderdale, Florida”.
F. Makovec et al. “New glutamic and aspartic derivatives with potent CCK-antagonistic activity” Eur. J. Med. Chem.-Chim. Ther., vol. 21, No. 1, 1986, pp. 9-20, XP009082343.
Baker et al., Journal of Pharmaceutical Science, 1966, 55(3), pp. 295-300, Abstract from STN search report.
Kerwin, et al., “Hybrid Cholecystokinin (CCK) Antagonists: New Implications in the Design and Modification of CCK Antagonists”, J. Med. Chem., 32:739-742 (1989).
Kuefner, et al., “Carboxypeptidase-Mediated Release of Methotrexate from Methotrexate α-Peptides”, Biochemistry, 28:2288-2297 (1989).
International Search Report, Issued Apr. 27, 2007, in PCT/US2006/027066.
Augeri, et al., “Potent and Selective Non-Cysteine-Containing Inhibitors of Protein Famesyltransferase”, Journal of Medicinal Chemistry, 41(22):4288-4300 (1998).
Boger, et al., “Conformationally Restricted Analogues Designed for Selective Inhibition of GAR Tfase Versus Thymidylate Synthase or Dihydrofolate Reductase”, Bioorg. Med. Chem., 8:1075-1086 (2000).
Database Caplus [Online], XP002413088, “Inhibitory Effect of Methotrexate on Matrix Metalloproteinase-1 (Collagenase) Production by Synovial Fibroblasts”, Database Accession No. 1997:137341.
Makovec, et al., “Structure-Antigastrin Activity Relationships of New (R)-4-Benzamido-5-oxopentanoic Acid Derivatives”, Journal of Medicinal Chemistry, 35(1):28-38 (1992).
Martinelli. et al., “Methotrexate Analogues. 12. Synthesis and Biological Properties of Some Aza Homologues”, Journal of Medicinal Chemistry, 22(7):869-874 (1979).
Piper, et al., “Syntheses of α- and γ-Substituted Amides, Peptides, and Esters of Methotrexate and Their Evaluation as Inhibitors of Folate Metabolism”, Journal of Medicinal Chemistry, 25(2):182-187 (1982).
Springer, et al., “Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)”, Journal of Medicinal Chemistry, 38(26):5051-5065 (1995).
PCT Invitation to Pay Additional Fees with Partial International Search Report from PCT Application No. PCT/US2006/027066, (2006).
Beyermann, et al., “Rapid Continuous Peptide Synthesis via FMOC Amino Acid Chloride Coupling and 4-(aminomethyl)piperidine Deblocking”, Journal of Organic Chemistry, 55(2):721-728 (1990).
Habermehl, et al., “Synthesis of N-[(3-ethoxycarbonylmethyl)-cyclohexyl]-azetidin-2-yl-propionic Acid Hydrochloride”; Zeitschrift Fuer Naturforschung, B: Chemical Sciences, 47(2):1779-1784 (1992).
Jobron, et al., “Solid-Phase Synthesis of New S-Glycoamino Acid Building Blocks”, Organic Letters, 2(15):2265-2267 (2000).
Moroder, et al., “Cytochrome C. Part I.: Synthesis of the Protected Hexadecapeptide (Sequence 1-16) of Baker's Yeast Iso-1-Cytochrome C”, Biopolymers, 12(3):477-492 (1973).
Okada, et al., “Amino Acids and Peptides LVI: Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor Binding Activity”, Tetrahedron, 55(50):14391-14406 (1999).
Suresh Babu, et al., “(Fluoren-9-ylmethoxy)carbonyl (Fmoc) Amino Acid Azides: Synthesis, Isolation, Characterisation, Stability and Application to Synthesis of Peptides”, J. Chem. Soc., Perkin Trust, 1:4328-4331 (2000).
Takahashi, et al., “Novel Matrix Metalloproteinase Inhibitors: Generation of Lead Compounds by the in Silico Fragment-Based Approach”, Bioorganic & Medicinal Chemistry, 13(14):4527-4543 (2005).
Wen, et al., “Synthesis of 9-Fluorenylmethoxycarbonyl-Protected Amino Aldehydes”, Tetrahedron: Asymmetry, 9(11):1855-1858 (1998).
Abbaszade, I. et al., “Cloning anc Characterization ofADAMTS11, an Aggrecanase from the ADAMTS Family”,J Biol Chem, 274(33):23443-23450 (1999).
Colige, A. et al., “cDNA Cloning and Expression of Bovine Procollagen I N-Proteinase: A New Member of the Superfamily of Zinc-Metalloproteinases with Binding Sites for Cells and Other Matrix Components”,Proc Natl Acad Sci USA, 94:2374-2379 (1997).
Kuno, et al., “Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene”,Journal of Biological Chemistry, 272(1):556-562 (1997).
Tang, BL, “ADAMTS: a Novel Family of Extracellular Matrix Proteases”,Int J. Biochem Cell Biol, 33:33-44 (2001).
Vazquez, F. et al., “Meth-1, a Human Ortholog of ADAMTS-1, and METH-2 are Members of a New Family of Proteins with Angio-Inhibitory Activity”,J Biol Chem, 274(33):23349-23357 (1999).
Feyfant Eric
How David Brian
Mansour Tarek Suhayl
Sabatini Joshua James
Skotnicki Jerauld Stanley
Chu Yong
Sabnis Ram W.
Wyeth LLC
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