Glucuronides of ester-containing anti-cholinergics

Details Glucuronides of ester-containing anti-cholinergics Glucuronides of ester-containing anti-cholinergics

1982-07-14

1984-09-11

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 75, 536 181, 536 182, 546268, A61K 3170, C12P 1944, C07H 1518

Patent

active

044711115

ABSTRACT:
An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.

REFERENCES:
patent: 3240777 (1966-03-01), Sarett et al.
patent: 3624200 (1971-11-01), Moffett
patent: 3767786 (1973-10-01), MacMillan
patent: 4153697 (1979-05-01), Hornke et al.
patent: 4292250 (1981-09-01), DeLuca et al.
Ando, et al., Synthesis of Mycophenolic Acid .beta.-D-Glucuronide and Its Antitumor Activity. J. Antibiotics, 23, 408-413 (1970).
Johnson, et al., Glucuronidation of Lipophilic Substrates. Prep. Biochem. 9, 391-406 (1979).

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