Glucuronic acid derivatives of opioid antagonists

Details Glucuronic acid derivatives of opioid antagonists Glucuronic acid derivatives of opioid antagonists

1988-03-26

1988-09-27

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 174, 536 181, A61K 3170, C07H 1524

Patent

active

047742305

ABSTRACT:
Intestine-specific delivery of an opioid antagonist can be accomplished without substantial central nervous system effects by administering the antagonist orally in the form of the glucuronide derivative.

REFERENCES:
Fujimoto et al., Chemical Abstracts, vol. 71, 1969, p. 130, No. 37250y.
Fujimoto et al., Chemical Abstracts, vol. 72, 1970, p. 131, No. 98055f.

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