Glucosyltransferase gene GTFE from amycolatopsis orientalis

Details Glucosyltransferase gene GTFE from amycolatopsis orientalis Glucosyltransferase gene GTFE from amycolatopsis orientalis

1997-09-05

1999-02-16

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435193, 4352523, 43525411, 4353201, 435325, 435410, 536 232, 935 22, 935 55, C12N 910, C12N 120, C12N 1500, C07H 2104

Patent

active

058719830

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

REFERENCES:
S. K. Chung, et al. "Biosynthetic Studies f Aridicin Antibiotics: Microbial Transformations and Glycosylations by Protoplasts." Journal of Antibiotics 39(5):652-659 (1986).
M. J. Zmijewski, Jr., and B. Briggs. "Biosynthesis of vancomycin: identification of TDP-glucose: aglycosyl-vancomycin glucosyltransferase from Amycolatopsis orientalis." FEMS Microbiology Letters 5:129-134.
M. J. Zmijewski, Jr., and J. T. Fayerman. Genetic and Biochemistry of Antibiotic Production Ed. L.c. Vining and C. Stuttard. Butterworth Heinemann, Boston. Chapter 18: "Glycopeptide Antibiotics." pp. 71-83.

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