Electrolysis: processes – compositions used therein – and methods – Electrolytic analysis or testing – For halogen or halogen containing compound
Patent
1996-03-18
1997-07-08
Gorgos, Kathryn L.
Electrolysis: processes, compositions used therein, and methods
Electrolytic analysis or testing
For halogen or halogen containing compound
204403, 2057775, 205787, 205792, 435 14, 435 28, 435817, G02N 2726, C12Q 154, C12Q 128
Patent
active
056457103
ABSTRACT:
A redox electrode for the rapid detection of glucose in aqueous media and a method for its use are provided. The redox electrode comprises an electrically conductive member such as copper, and a redox membrane in direct contact with said electrically conductive member. The redox membrane comprises a polymer matrix such as PVC containing a plasticizer, and a complex of 7,7,8,8-tetracyanoquinodimethane and tetrathiafulvalene with the complex having a burgundy-red coloration and characterized by a broad absorption from about 340 nm to about 550 nm and weaker absorption between about 650 nm to about 800 nm having about six small peaks with an absorption maximum at about 750 nm. Glucose is rapidly assayed by bringing the redox electrode and a reference electrode into simultaneous contact with an aqueous medium containing KCl, phosphate buffer, glucose oxidase, peroxidase, and 3,3',5,5'-tetramethylbenzidine dihydrochloride. The potential of the redox membrane is then monitored until it is stable. A sample containing glucose is added to the aqueous medium, and the change of potential of the redox electrode, which is related to glucose concentration, is then observed. In a variant of this method, the redox electrode is treated with ascorbic acid before a glucose oxidation to magnify the potential difference generated, and after oxidation to rapidly collapse the potential and prepare the electrode for another analysis.
REFERENCES:
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JAPIO abstract of JP58105055 (Akihiro et al.) Jun. 22, 1983.
WPIDS abstract of JP58105055 (Akihiro et al.) Jun. 22, 1983.
CAPlus abstract of JP58105055 (Akhiro et al.) Jun. 22, 1983.
JAPIO abstract of JP60085359 (Kazuhiro et al.) May 14, 1985.
Hale et al., "Cyclic Voltammetry at TCNQ and TTF-TCNQ Modified Platinum Electrodes: A Study of the Glucose Oxidase/Glucose and Galactose Systems", Synthetic Materials, 28(1989), C853-C858) 1989.
Aronoff Marvin S.
Biomedix, Inc.
Gorgos Kathryn L.
Noguerda Alexander
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