Glucose sensor

Details Glucose sensor Glucose sensor

2007-07-03

2007-07-03

Wax, Robert A. (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

11078934

ABSTRACT:
Methods are provided for the modulation of hSGLT3 protein glucosensor activity. The sensor is expressed in cholinergic neurons that regulate muscle activity, and in tissues including the brain and pacreas. The present invention also provides methods of identifying therapeutic compounds that modify the function of these sensors. Such therapeutic compounds have a functional effect on regulators of muscle activity, including gastrointestinal smooth muscles; on regulation of weight and metabolism; regulation of pancreatic function, including glucagons release; and in taste perception.

REFERENCES:
Diez-Sampedro et al., “HSGLT3 a human glucose sensor,” Experimental Biology 2003, Abstract # 583.20, Apr. 11-15, 2003, San Diego, CA.
Scheepers et al., “The Glucose Transporter Families SGLT and GLUT: Molecular Basis of Normal and Aberrant Function,” J. Parenteral and Enteral Nutrition, vol. 28, No. 5, pp. 364-371, Sep./Oct. 2004.
Genbank Accession No. NM—014227, Jung, The Sodium/Substrate Symporter Family: Structural and Functional Features, FEBS Lett. 529(1): 73-77 (2002).
Diez-Sampedro et al., A Glucose Sensor Hiding in a Family of Transporters, PNAS, 2003, 100(20): 11753-11758.

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