Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1996-08-23
2000-09-26
Soderquist, Arlen
Chemistry: analytical and immunological testing
Biological cellular material tested
356329, 25033902, 25033905, 25033906, 25033907, 25033909, 25033912, 2503415, 422 8205, 422 8209, 436 66, 436 67, 436 95, G01N 2131, G01N 2125, G01N 3300
Patent
active
061241342
ABSTRACT:
A method of and apparatus for determining stable and labile glycated compound levels in blood. Electromagnetic energy covering a multiplicity of wavelength bands within a wavelength range from 380 nm to 2500 nm is directed into a sample volume containing blood. Portions of the energy representative of both the source energy and energy after interacting with material within the sample volume are collected. The energy portions carry information relating to the source energy and the levels of labile and stable compounds within the sample volume, respectively. The portions are converted into electrical signals representative of the intensities of the respective portions in each of the multiplicity of wavelength bands. The electrical signals are pretreated in accordance with known information to remove deviations from established reference conditions to form data signals that are a function of the fractional portion of the energy in each of the wavelength bands absorbed and scattered by the material in the measurement volume. Selected groups of the data signals are processed in accordance with chemometric models developed from analysis of such data signals together with known values of the analytes derived from measurements on a calibration set of samples larger in number than the number of wavelength bands included in the set of the selected groups of data signals to develop analyte signals representative of the amounts of glycated compounds for which chemometric models have been developed and utilized. The analyte signals may be stored and displayed in a form suitable for medical use.
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