Chemistry: electrical and wave energy – Apparatus – Electrolytic
Patent
1994-01-25
1997-12-09
Bell, Bruce F.
Chemistry: electrical and wave energy
Apparatus
Electrolytic
204415, 204406, 435817, 4352871, 128635, G01N 2726
Patent
active
056956231
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The invention is directed to a device for measuring and displaying the glucose concentration in the blood.
Such glucose measuring devices for diabetics are already known and substantially comprise the actual measuring device (glucometer) and exchangeable sensors (glucosensors) which can be inserted in the latter and on which a small quantity of the blood to be determined is placed. The blood required for this is removed by the user in a conventional manner by means of pricking the fingertip. When the sensor is inserted its biomembrane makes electrical contact with the measuring device, so that the changes in voltage and/or current of the active biomembrane of the sensor brought about by the different glucose contents are transmitted to the measuring device. The relevant measuring range of blood glucose in diabetics is between 4 and 15 mmol/l (=70-270 mg/dl). The measuring range of such devices is also typically 3-16 mmol/l (=50-300 mg/dl) so as to be able to measure in the clinical range as well.
The glucose measuring devices according to the prior art are too complicated, difficult to operate, unreliable and therefore also dangerous for the patient. In particular, it has been shown that the biomembrane of glucose sensors, whose active component consists of an unstable enzyme, e.g. glucose oxidase, is difficult to manufacture in a reproducible manner on the one hand and is subject to various changes in its characteristics caused by aging on the other hand.
SUMMARY OF THE INVENTION
The invention seeks to provide a remedy for this. The object of the invention is to provide a glucose measuring device by means of which it is possible to regulate all essential influencing variables already during the manufacture of the glucose measuring device by means of a unique calibration which cannot be altered for the patient while simultaneously taking into account the changes in the influencing variables caused by aging.
The invention meets this object by means of a glucose measuring device including disposable sensors comprising a biomembrane and a display device which can be calibrated and works on the basis of the glucose concentration diagram to evaluate the measurement results of the sensors. The display device comprises a computer with a time measuring device, whose zero setting can be correlated with the date of manufacture of the disposable sensors in an irreversible manner. An irreversible calibration of the glucose concentration diagram is provided which corresponds to the characteristics of the biomembrane of the disposable sensors at the time of their manufacture. At least one automatic and irreversible correction of the glucose concentration diagram which is influenced by the time measuring device is provided which takes into account the time-dependent characteristics of the biomembrane of the disposable sensors.
In practice, the glucose measuring device, according to the invention, is given to the patient as a complete package in the form of a display device (computer with time measuring device) together with 200-300 sensors. This quantity of sensors is generally sufficient for a half year to one whole year. The measuring and evaluating characteristics of the display device and disposable sensors, which characteristics are specifically adapted to one another, and the adaptation of the evaluating parameters to the aging-dependent measurement parameters of the sensors, which is made possible by means of the internal time measuring device of the display device, guarantees a high accuracy of the measuring results on the one hand and ensures a high degree of safety in operation on the other hand.
The advantages achieved by means of the invention substantially consist in that it is no longer necessary to calibrate the device to the disposable sensors which are to be contacted, specifically neither a first calibration when starting operation, nor a secondary calibration during the life of the device is necessary as a result of the glucose measuring device, according to the inventio
REFERENCES:
patent: 4953552 (1990-09-01), De Marzo
patent: 5108889 (1992-04-01), Smith
Michel Peter
Michel Willy
Bell Bruce F.
Disetronic Licensing AG
LandOfFree
Glucose measuring device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glucose measuring device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glucose measuring device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1604530