Glucose isomerases having altered substrate specificity

Details Glucose isomerases having altered substrate specificity Glucose isomerases having altered substrate specificity

1991-01-04

1994-05-10

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435234, C12P 1924, C12N 992

Patent

active

053106652

ABSTRACT:
A method for selecting amino acid residues is disclosed which upon replacement will give rise to an enzyme with an altered substrate specificity. New mutant glucose isomerases with an altered substrate specificity are provided according to this method. These altered properties are useful in starch degradation and in other sugar conversion reactions.

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Wilks et al., Science (1988) 242:1541-1544.
Lindberg et al., Nature (1989) 339:632-634.
Amore et al., Nucl. Acids. Res. (1989) 17(18):7515.

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