Glucose-induced inactivation/degradation-resistant...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi

Reexamination Certificate

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C435S320100, C536S023100

Reexamination Certificate

active

08053224

ABSTRACT:
The present invention relates to a glucose-induced inactivation/degradation resistant transporter gene and use thereof, and more particularly to a brewery yeast having excellent assimilability of oligosaccharides (maltose, maltotriose, etc.), an alcoholic beverage produced using the yeast, and so on. In particular, the present invention relates to a glucose-induced inactivation/degradation resistant transporter such as Mal21p, etc., a gene encoding the same, a method of producing an alcoholic beverage using the same; and so on.

REFERENCES:
patent: 5190877 (1993-03-01), Osinga et al.
patent: 7314974 (2008-01-01), Cao et al.
patent: 1-153082 (1989-06-01), None
patent: 6-245750 (1994-09-01), None
Brondijk et al. “Catabolite Inactivation of Wild-type and Mutant Maltose Transport Proteins inSaccharomyces cerevisiae” (1998)J. Biol. Chem. 273(25):15352-15357.
Medintz et al. “A PEST-like Sequence in the N-Terminal Cytoplasmic Domain ofSaccharomycesMaltose Permease is Required for Glucose-Induced Proteolysis and Rapid Inactivation of Transport Activity” (2000)Biochemistry39(15):4518-4526.
Gadura et al. “Sequences in the N-terminal Cytoplasmic Domain ofSaccharomyces cerevisiaeMaltose Permease are Required for Vacuolar Degradation but not Glucose-Induced Internalization” (2006)Curr. Genet. 50(2):101-114.
Kodama et al. “Improvement of Maltose Fermentation Efficiency: Constitutive Expression ofMALGenes in Brewing Yeasts” (1995)J. Am. Soc. Brew. Chem. (1995) 53(1):24-29.
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Yao et al. “Primary Structure of the Maltose-Permease-Encoding Gene ofSaccharomyces carlsbergensis” (1989)Gene79:189-197.
Cheng et al. “The Maltose Permease Encoded by theMAL61Gene ofSaccharomyces cerevisiaeExhibits Both Sequence and Structural Homology to Other Sugar Transporters” (1989)Genetics123:477-484.
Feuermann et al. “Sequence of a 9.8 kb Segment of Yeast Chromosome II Including the Three Genes of theMAL3Locus and Three Unidentified Open Reading Frames” (1995)Yeast11:667-672.
U.S. Appl. No. 12/442,143 to Hatanaka et al., entitled “Glucose-Induced Inactivation/Degradation-Resistant Transporter Gene and Use Thereof” which application is the National Stage of PCT/JP2008/066237, filed Sep. 9, 2008.
U.S. Appl. No. 12/442,131 to Hatanaka et al., entitled “Hybrid Alpha-Glucoside Transporter” which application is the National Stage of PCT/JP2008/066239, filed Sep. 9, 2008.

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