Glucose dependent release of insulin from glucose sensing...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S426000, C530S303000

Reexamination Certificate

active

07316999

ABSTRACT:
Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the rate of insulin release from the depot increases with an increased glucose concentration and decreases with a decreased glucose concentration.

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Journal of Organic Chemistry, Eggert et al., (1999) vol. 64, pp. 3846-3852.

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