Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving glucose or galactose
Reexamination Certificate
2007-07-17
2007-07-17
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving glucose or galactose
C435S069100, C435S252310, C435S471000, C435S190000, C435S026000, C435S189000, C536S023200
Reexamination Certificate
active
10517702
ABSTRACT:
Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH derived fromAcinetobacter calcoaceticusis replaced with other amino acid residues and has an inhibition constant (Ksi) of 200 mM or more. The modified water-soluble PQQGDH of the invention can be utilized for measuring glucose levels in the presence of high concentrations of glucose because of the low substrate inhibition by glucose.
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Cleton-Jansen A-M et al., “Glucose dehydrogenase-B Pyrroloquinoline-quinone Presursor (EC 1.1.99.17)” Swiss-Prot, Oct. 16, 2001 XP002203013.
Hiroshi Hayade et al., “CSJ: The Chemical Society of Japan Dai 79 Shunki Nenkai—Koen Yokoshu II”, CSJ: The Chemical Society of Japan, Mar. 15, 2001, p. 897.
A. Oubrie et al., “Structure and mechanism of soluble quinoprotein glucose dehydrogenase”, EMBO J., 1999, vol. 18, No. 19, p. 5187-94.
A. Oubrie et al., “The 1.7 A crystal structure of the apo from of the soluble quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus reveals a novel internal conserved sequence repeat”, J. Mol. Biol., 1999, vol. 289, No. 2, p. 319-33.
Meah M. Y.
Prouty Rebecca E.
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