Glucose-based compounds with affinity to P-selectin

Details Glucose-based compounds with affinity to P-selectin Glucose-based compounds with affinity to P-selectin

2007-12-04

2007-12-04

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S559000, C514S460000, C514S054000, C435S105000, C536S001110, C536S004100

Reexamination Certificate

active

10530601

ABSTRACT:
The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation of pharmaceutical compositions for the treatment of disorders associated with P-selectin, to conjugates, pharmaceutical carriers and drug delivery systems comprising said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.

REFERENCES:
patent: 5604207 (1997-02-01), DeFrees et al.
patent: 5830871 (1998-11-01), Wong et al.
patent: 5916876 (1999-06-01), Heavner et al.
Wong, C-H; J.Am. Chem. Soc. 1997, 119, 8152-8158.
Lin et al., “Synthesis of Sialyl Lewis X Mimetics as Selectin Inhibitors by Enzymic Aldol Condensation Reactions”,Bioorganic&Medicinal Chemistry, vol. 7, No. 3, 1999, p. 427.
Weitz-Schmidt et al., “Selectin/Glycoconjugate Binding Assays for the Identification and Optimization of Selectin Antagonists”,Analytical Biochemistry, vol. 273, No. 1, 1999, pp. 81-88.

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