Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving glucose or galactose
Patent
1979-05-07
1982-03-02
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving glucose or galactose
204195B, 435 25, 435180, 435182, C12Q 126, C12Q 154, C12N 1108
Patent
active
043178790
ABSTRACT:
A membrane and the method of making the same is disclosed for use with glucose analyzers to detect the level of glucose in liquid mediums such as whole blood. The membrane comprises a thin base wafer of a hydrophobic fluorocarbon material such as polytetrafluoroethylene (TEFLON). The wafer is initially etched by removing surface fluorides to produce a hydrophilic surface and is then contacted with a mixed reagent formed by combining in a volume ratio of about 1:1:1 about 4% paraformaldehyde in water, about 5% bovine serum albumin in water and about 10% glucose oxidase in water. The resultant membrane contains glucose oxidase covalently bonded to the surface of the base wafer.
REFERENCES:
patent: 3542662 (1970-11-01), Hicks et al.
patent: 3933593 (1976-01-01), Sternberg
patent: 3972274 (1976-09-01), Newman
patent: 4004979 (1977-01-01), Arvameas et al.
Updike et al, Continuous Glucose Monitor Based on an Immobilized Enzyme Electrode Detector, J. Lab. Clin. Med., vol. 93, No. 4, 4/79 (pp. 518-527).
Busby Michael G.
Hartwig Diane E.
Airco, Inc.
Cassett Larry R.
Naff David M.
Rathbun Roger M.
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