Glucose-6-phosphate uptake inhibitors and novel uses thereof

Details Glucose-6-phosphate uptake inhibitors and novel uses thereof Glucose-6-phosphate uptake inhibitors and novel uses thereof

1995-01-19

1997-07-01

Seidleck, James J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 62, 514724, 514727, 514729, 514738, 514740, A01N 4304, A61K 3170

Patent

active

056438834

ABSTRACT:
The present invention provides a composition of matter comprising an inhibitor of glucose-6-phosphate uptake. Also provided is a method of inhibiting the import of glucose-6-phosphate into the endoplasmic reticulum of a cell, comprising the step of adminstering a pharmacologically effective dose of a glucose analogue to said cell. Further provided is a method of inhibiting intracellular endoplasmic reticular concentrations of calcium, comprising the step of administering to a cell a pharmacologically effective dose of a glucose-6-phosphate uptake inhibitor.

REFERENCES:
CA 120:131,345 (1994).

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