Glucose-6-phosphate dehydrogenase deficient mice and methods of

Details Glucose-6-phosphate dehydrogenase deficient mice and methods of Glucose-6-phosphate dehydrogenase deficient mice and methods of

1997-12-05

2000-05-30

LeGuyader, John I.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 8, 800 13, 800 14, 800 3, 4353201, 435375, 435354, 435355, 435455, A01K 6700, C12N 1585, C12N 1563, G01N 3300

Patent

active

060692979

ABSTRACT:
Mice which produce measurable levels of glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells can be used as animal models to evaluate new drugs for risk of inducing hemolytic anemia in G6PD-deficient individuals, and for pre-clinical evaluation of gene therapy protocols to correct G6PD deficiency. Deficient and wild-type cells can be distinguished using a tetrazolium dye, and the numbers of each type of cell counted before and after exposure of the cells to the drug or therapy.

REFERENCES:
Luzzatto, L. About hemoglobins, G6PD and parasites in red cells. Experientia 51. 206-208, 1995.
Pandolfi, P. et al. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD). EMBO Journal. (14) 1995. p 5209-5215.
Martini, G. et al. A new lease of life for an old enzyme. Bioessays, Aug. 1996. (18) p 631-7.
Capecchi, M. Targeted gene replacement. Scientific American. Mar. 1994 (270) pp. 34-41.
Bradley, A. et al. Modifying the mouse: design and desire. Biotechnology 1992 (10) pp. 534-539.

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