Glucosaminyl muramyl peptide derivatives

Details Glucosaminyl muramyl peptide derivatives Glucosaminyl muramyl peptide derivatives

1983-05-13

1985-10-08

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045459320

ABSTRACT:
Novel glucosaminyl muramyl peptide derivatives of the formula: ##STR1## wherein X is hydrogen atom or a group of the formula: R.sub.1 CO--, Y is hydroxy group or a group of the formula: --OR.sub.2, ##STR2## R.sub.1 is an alkyl or alkenyl group, R.sub.2 is a lower alkyl group or a phenylalkyl group, R.sub.3 and R.sub.4 are the same or different and are each hydrogen atom or an alkyl group, Y' is hydroxy group or a group of the formula: --OR.sub.2 or ##STR3## (D) and (L) mean the configuration, provided that when X is hydrogen atom, Y is a group of the formula: ##STR4## and their pharmaceutically acceptable salts. They have excellent biological activities such as potentiating activity of nonspecific resistance to microbial infections and immunostimulant activity and hence are useful in the prophylaxis and treatment of various microbial infections.

REFERENCES:
Chemical Abstracts, 100, 640 (1984), Abst. No. 68710v.
Chemical Abstracts, 99, 529 (1983), Abst. No. 211141d.
Chemical Abstracts, 86, 169 (1977), Abst. No. 151982y.
Chemical Abstracts, 96, 750 (1982), Abst. No. 181627k.
Dezelee et al., Biochemistry, 11, No. 4, 823-831, (1970).
Ellouz et al., Biochem. & Biophysical Res. Commu., 59, No. 4, 1317-1325, (1974).
Yamamura et al., Proc. Japan Acad., 52, 58-61, (1976).

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