Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-10-12
2008-12-16
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S025000, C514S035000
Reexamination Certificate
active
07465713
ABSTRACT:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents agroup represented by the general formula:(wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
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Fujikura Hideki
Fushimi Nobuhiko
Isaji Masayuki
Nakabayashi Takeshi
Nishimura Toshihiro
Jiang Shaojia Anna
Kissei Pharmaceutical Co. Ltd.
McIntosh, III Traviss C
Sughrue & Mion, PLLC
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