Glucopyranosyloxypyrazole derivatives and medicinal use thereof

Details Glucopyranosyloxypyrazole derivatives and medicinal use thereof Glucopyranosyloxypyrazole derivatives and medicinal use thereof

2007-11-13

2007-11-13

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S035000, C514S866000, C536S004100, C536S018100

Reexamination Certificate

active

10469140

ABSTRACT:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:wherein R1, R2and R3represent a hydrogen atom or a halogen atom; R4represents a lower alkyl group or a halo(lower alkyl) group; and R5represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, etc., a pharmaceutically acceptable salt thereof or a prodrug thereof., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.

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