Glucopyranosyloxypyrazole derivatives and medicinal use thereof

Details Glucopyranosyloxypyrazole derivatives and medicinal use thereof Glucopyranosyloxypyrazole derivatives and medicinal use thereof

2006-08-08

2006-08-08

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S035000, C536S004100, C536S017400, C536S018100

Reexamination Certificate

active

07087579

ABSTRACT:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:wherein one of Q and T represents a group represented by the general formula:while the other represents a lower alkyl group or a halo(lower alkyl) group; R1represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.

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Kenneth L. Kees, et al.; New Potent Antihyperglycemic Agents in db/db Mice: synthesis and Structuc-Activity Relationship Studies of (4-Substitutedbenzyl) (Trifluoromethyl) pyrazoles and-pyrazolones, J. Med. Chem., 1990, vol. 39, No. 20, pp. 3920-3928.

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