Glucopyranosyloxybenzylbenzene derivatives and medicinal use...

Details Glucopyranosyloxybenzylbenzene derivatives and medicinal use... Glucopyranosyloxybenzylbenzene derivatives and medicinal use...

2002-02-13

2009-06-02

McIntosh, III, Traviss C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S004100, C536S017200, C536S017500, C536S017900

Reexamination Certificate

active

07541341

ABSTRACT:
The present invention provides glucopyranosyloxybenzylbenzene derivatives represented by the general formula:wherein P represents a hydrogen atom or a group forming a prodrug; R1represents a hydrogen atom, an optionally substituted amino group, a carbamoyl group, an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, etc.; R2represents a hydrogen atom or a lower alkyl group; and R3represents an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkylthio group, etc., which have an improved oral absorption, and exert an inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, or pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

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Oku A. et al, Antidiabetic effect of T-1095, an inhibitor of Na(+)-glucose contransporter, in neonatally streptozotocin-treated rats, Eur. J. Pharmacol., 2000, vol. 391, No. 1-2, pp. 183 to 192.
Oku A. et al., Antihyperglycemic effect of T-1095 via inhibition of renal Na+ glucose cotransporters in streptozotocin-induced diabetic rates, Biol. Pharm. Bull., 2000, vol.. 23, No. 12, pp. 1434 to 1437.

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