Glucopyranosyloxybenzylbenzene derivatives and medicinal...

Details Glucopyranosyloxybenzylbenzene derivatives and medicinal... Glucopyranosyloxybenzylbenzene derivatives and medicinal...

2005-03-29

2005-03-29

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S035000, C536S004100, C536S018100

Reexamination Certificate

active

06872706

ABSTRACT:
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula:wherein P represents a group forming a prodrug; and R represents a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group or a lower alkoxy-substituted (lower alkylthio) group, which have an improved oral absorption and can exert an excellent inhibitory activity in human SGLT2 in vivo and which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same.

REFERENCES:
patent: 4598068 (1986-07-01), Samreth et al.
patent: 5424406 (1995-06-01), Tsujihara et al.
patent: 5731292 (1998-03-01), Tsujihara et al.
patent: 6683056 (2004-01-01), Washburn et al.
patent: 20020111315 (2002-08-01), Washburn et al.
patent: 0 598 359 (1994-05-01), None
patent: WO 0168660 (2001-09-01), None
patent: WO 0174834 (2001-10-01), None
patent: WO 0228872 (2002-04-01), None
Akira Oku, et al; Antidiabtic effect of T-1095, an inhibitor of Na+-glucose cotransporter, in nconatally streptozotocin-treated rats; European Journal of Pharmacology 391 (2000)183-192.
Mariana Panayotova-Heiermann, et al.; Sugar Binding to Na+/Glucose Cotransporters Is Determined by the Carboxyl-terminal Half of the Protein; The Journal of Biological Chemistry; vol. 271, No. 17, Issue of Apr. 26, 1996; pp. 10029-10034, 1996.

Affiliated with

Also associated with

Rating

Glucopyranosyloxybenzylbenzene derivatives and medicinal... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glucopyranosyloxybenzylbenzene derivatives and medicinal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glucopyranosyloxybenzylbenzene derivatives and medicinal... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3433149