Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-03-15
1996-10-22
Trinh, Ba K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546212, 546237, 549 51, C07D40914
Patent
active
055678203
ABSTRACT:
A compound of the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.
REFERENCES:
patent: 4418068 (1983-11-01), Jones
Greene et al, "Protective Groups in Organic Synthesis", pp. 77-82, 90, 92-93, 2 .sup.nd ed., 1991.
Frolik et al, "In Vivo and In Vitro Metabolism of Raloxifene" Am. Soc. Bone & Min. Res., Tampa, Sep. 18-22, 1993.
Lindstrom et al "Disposition and Metabolism of New Benzthiophene Antiestrogin in Rats, Dogs, Monkeys, " Xenobiotica, 14(11), 841-847 (1984).
Black et al., "The Relationship of the Antiestrogenic Efficacy of LY156758 to its Pharmacokinetics and Metabolism following Oral Administration to Adult Ovariectomized Rats", 7th Int'l Congress of Endrocrin, Quebec City, Jul. 1-7, 1984, ABS 323.
Lantz et al., "HPLC Determination of Raloxifene Before and After Hydrolysis of Human Plasma", AAPS, Orlando FL, Nov. 14-18, 1993.
Dodge Jeffrey A.
Lindstrom Terry D.
Lugar, III Charles W.
Staten Gilbert S.
Boone David E.
Eli Lilly and Company
Sales James J.
Trinh Ba K.
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