Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2005-08-16
2005-08-16
Rao, Manjunath (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S004000, C435S006120, C435S252300, C435S320100, C435S069100, C435S071100, C435S440000, C435S325000, C435S254100, C435S410000, C536S023200, C536S023700
Reexamination Certificate
active
06929935
ABSTRACT:
This invention relates to an novelGluconobacter oxydans2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encodingG. oxydans2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolatedG. oxydans2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind toG. oxydans2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolatedG. oxydans2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of usingG. oxydans2-ketoreductase in various reactions for industrial or pharmaceutical applications.
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Cino Paul M.
Goldberg Steven L.
Johnston Robert M.
Nanduri Venkata B.
Patel Ramesh N.
Bristol--Myers Squibb Company
Pak Yong
Rao Manjunath
Sher Audrey F.
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