Glucocorticoid receptor ligands for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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Details

C552S549000

Reexamination Certificate

active

07141559

ABSTRACT:
This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

REFERENCES:
patent: 5462933 (1995-10-01), Kramer et al.
patent: 5780444 (1998-07-01), Kahne
patent: EP 0 489 423 (1991-12-01), None
patent: B1 9827986 (1998-02-01), None
patent: WO 99/44616 (1999-09-01), None
patent: B2 0058337 (2000-05-01), None
Kramer, W. and Wess, G.: European Journal of Clinical Investigation, “Bile acid transport systems as pharmaceutical targets”, Vol. 26, p. 715-732 (1996).
Kramer, Werner, et al.: The Journal of Biological Chemistry, “Liver-specific Drug Targeting by Coupling to Bile Acids”, vol. 287, No. 26, p. 18598-18604 (1992).

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