Glucan sulfate, stabilized fibroblast growth factor composition

Details Glucan sulfate, stabilized fibroblast growth factor composition Glucan sulfate, stabilized fibroblast growth factor composition

1989-06-02

1994-05-24

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514 23, 514970, 530399, A61K 3736, A61K 3724

Patent

active

053148720

ABSTRACT:
Fibroblast growth factor (FGF) or a mutein of FGF is stabilized by bringing FGF or a mutein of FGF into contact with a glucan sulfate in an aqueous medium. Thus obtained composition comprising (a) FGF or a mutein of FGF and (b) a glucan sulfate is stabilized, so that it can be advantageously administered to warm-blooded animals.

REFERENCES:
patent: 4717717 (1988-01-01), Finkenaur
patent: 5013714 (1991-05-01), Lindstrom
Gospodarowicz et al. J. of Cellular Physiology, 128, 475-484 (1986).
Schreiber et al. Proc. Natl. Acad. Sci. USA, 82, 6138-6142 (1985).
Seno et al. Biochem. Biophys. Res. Commun. 151, 701-708 (1988).
Biotechnology Products Catalog 1993, p. 69.

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