Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-02-09
2011-12-27
Thomas, Timothy (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S072000, C549S059000, C514S448000
Reexamination Certificate
active
08084489
ABSTRACT:
The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have glucagon receptor antagonist or inverse agonist activity, as well as methods of using these compounds and intermediates and methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising N compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
REFERENCES:
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patent: WO2005/118542 (2005-12-01), None
patent: WO2005/123668 (2005-12-01), None
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Kurukulasuriya et al: “Biaryl amide 1-16 glucagon receptor antagonists” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 14, No. 9, 2004, pp. 2047-2050, XP002339903 ISSN: 0960-894X table 1.
Duffy, J.L.: “Discovery and investigation 1-16 of a novel class of thiophene-derived antagonists of the human glucagon receptor” Bioorganic & Medicinal Chemistry Letters, vol. 15, 2005, pp. 1401-1405, XP002392897 table 1.
Chappell Mark Donald
Conner Scott Eugene
Tripp Allie Edward
Zhu Guoxin
Eli Lilly and Company
Heyer Dennis
Thomas Timothy
Wood Dan L.
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