Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2006-11-10
2011-12-13
Badio, Barbara P (Department: 1613)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C562S450000
Reexamination Certificate
active
08076374
ABSTRACT:
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
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Kurukulasuriya et al.; Biaryl amide glucagon receptor antagonists,Bioorganic&Medicinal Chemistry Letters, vol. 14, No. 9, pp. 2047-2050 (2004).
Beasley, Helen L. et al., “Development of a Panel of Immunoassays for Monitory DDT, Its Metabolites, and Analogs in Food and Environmental Matrixes”,Journal of Agricultural and Food Chemistry, 46(8), pp. 3339-3352; compound Hapten VI, 1998.
Kundu, B et al., “Identification of novel alpha-glucosidase inhibitors by screening libraries based on N-′r-(Benzyloxy) benzoyl! Alanine derivatives”,Chemical Abstracts Service, 5(7), pp. 545-550, 2002.
Chappell Mark Donald
Conner Scott Eugene
Hipskind Philip Arthur
Lamar Jason Eric
Zhu Guoxin
Badio Barbara P
Eli Lilly and Company
Townsley Sara E
Wood Dan L.
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