Glucagon receptor antagonists, preparation and therapeutic uses

Details Glucagon receptor antagonists, preparation and therapeutic uses Glucagon receptor antagonists, preparation and therapeutic uses

2011-01-04

2011-01-04

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C562S450000

Reexamination Certificate

active

07863329

ABSTRACT:
The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

REFERENCES:
patent: 5811459 (1998-09-01), Breault et al.
patent: WO 03/048109 (2003-06-01), None
patent: WO 2004/002480 (2004-01-01), None
patent: WO 2004/056763 (2004-07-01), None
patent: WO 2006/102067 (2006-09-01), None
Type 2 diabetes [online] retrieved on Feb. 14, 2010 from the internet. URL http://www.mayoclinic.com/health/type-2-diabetes/DS00585.
Kurukulasuriya et al.; Biaryl amide glucagon receptor antagonists,Bioorganic&Medicinal Chemistry Letters, pp. 2047-2050, vol. 14, No. 9, (2004).
Beasley, et al., Development of a Panel of Immunoassays for Monitory DDT, Its Metabolites, and Analogs in Food and Environmental Matrixes,Journal of Agricultural and Food Chemistry, 46(8), pp. 3339-3352; compound HAPTEN VI, 1998.
Kundu B, et al., Identification of novel alpha-glucosidase inhibitors by screening libraries based on N-'r-(Benzyloxy) benzoyl! Alanine derivatives,Chemical Abstracts Service, 5(7), pp. 545-550, 2002.

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