Glucagon analogs with serine replacements

Details Glucagon analogs with serine replacements Glucagon analogs with serine replacements

1994-06-08

1996-01-02

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530308, A61K 3826, C07K 1400, C07K 14605

Patent

active

054808677

ABSTRACT:
Glucagon analogs characterized principally by the removal or replacement of the 9-aspartic acid residue or its replacement with another amino acid residue together with replacement of the 16-serine residue and possible replacement of the 11-serine residue and 21-aspartic acid residue with or without a histidine at the amino terminal are useful adjuncts to insulin therapy.

REFERENCES:
patent: 4879273 (1989-11-01), Merrifield
patent: 5143902 (1992-09-01), Merrifield et al.
Unson et al., 1994, "Multiple-site replacement analogs of glucagon. A molecular basis for antagonists design", J. Biol. Chem 269:12548-51.
Unson and Merrifield, 1994, "Identification of an essential serine residue in glucagon: Implication for an active site triad", Proc. Natl. Acad. Sci USA 91:454-58.
Unson et al., 1993, "The role of histidine-1 in glucagon action", Arch. Biochem. Biophys. 300:747-50.
Unson et al., 1991, "Position 9 replacement analogs of glucagon uncouple biological activity and receptor binding", J. Biol. Chem. 266:2763-66.
Unson et al., 1989, "Glucagon antagonists: contribution to binding and activity of the amino-terminal sequence 1-5, position 12, and the putative alpha-helical segment 19-27", J. Biol. Chem. 264:789-94.

Affiliated with

Also associated with

Rating

Glucagon analogs with serine replacements does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Glucagon analogs with serine replacements, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glucagon analogs with serine replacements will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-235198