Glucagon analogs with serine replacements

Details Glucagon analogs with serine replacements Glucagon analogs with serine replacements

1995-06-07

1997-09-09

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530308, A61K 3826, C07K 1400, C07K 14605

Patent

active

056657056

ABSTRACT:
Glucagon analogs characterized principally by substitution of amino acid residues at positions 9, 11, 16, and 21 with or without a histidine residue at the amino terminus are useful adjuncts to insulin therapy.

REFERENCES:
patent: 4879273 (1989-11-01), Merrifield et al.
patent: 5143902 (1992-09-01), Merrifield et al.
Flanders et al. (1984) J. Biol. Chem. 259:7031-7.
Unson et al., (1994) J. Biol. Chem 269:12548-51.
Unson et al. (1994) Proc. Natl. Acad. Sci. USA 91:454-58.
Unson et al. (1993) Arch. Biochem. Biophys. 300:747-50.
Unson et al. (1991) J. Biol. Chem. 266:2763-66.
Unson et al. (1989) J. Biol. Chem. 264:789-94.
Breddam et al. (1987) Carlsberg Res. Commun. 55-63.
Unson et al. (1987) Biochemistry 84:4083-7.

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