GLP-2 formulations

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S308000, C530S399000, C530S324000, C435S004000, C435S287100

Reexamination Certificate

active

07056886

ABSTRACT:
The invention is directed to formulations of GLP-2 peptides and analogs thereof exhibiting superior stability following storage and/or exposure to elevated temperatures. The GLP-2 compositions comprise a GLP-2 peptide or an analog thereof, a phosphate buffer, L-histidine, and mannitol.

REFERENCES:
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patent: 5652216 (1997-07-01), Kornfelt et al.
patent: 5912229 (1999-06-01), Thim et al.
patent: 5952301 (1999-09-01), Drucker
patent: 5997856 (1999-12-01), Hora et al.
patent: 6120761 (2000-09-01), Yamazaki et al.
patent: 97/39031 (1997-10-01), None
patent: 98/03547 (1998-01-01), None
patent: 99/43361 (1999-09-01), None
Buhl et al., Naturally Occurring Products of Proglucagon 111-160 in the Porcine and Human Samll Intestine, J. Biol. Chem. 263, 8621-8624 (1988).
Lund et al., Anglerfish Islet Pre-proglucagon II, Nucleotide and corresponding amino acid Sequenmce of the cDNA, J. Biol. Chem. 258, 3280-3284 (1983).

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