GLP-1 gene delivery for the treatment of type 2 diabetes

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S023100

Reexamination Certificate

active

07374930

ABSTRACT:
This patent discloses compositions and methods of use thereof to normalize the blood glucose levels of patients with type 2 diabetes. It relates particularly to a plasmid comprising a chicken β actin promoter and enhancer; a modified GLP-1 (7-37) cDNA (pβGLP1), carrying a furin cleavage site, which is constructed and delivered into a cell for the expression of active GLP-1.

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