Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Reexamination Certificate
2007-06-26
2007-06-26
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
C436S069000
Reexamination Certificate
active
10865608
ABSTRACT:
The instant invention describes a method for establishing the hemostatic competence of blood, wherein the steps of the method include obtaining a blood sample from a subject, contacting the blood sample with an effective amount of tissue factor under conditions conducive to coagulating blood; and detecting the amount of thrombin in the blood sample at a pre-determined time point. The invention also describes a method for testing the capacity of an individual subject to produce thrombin, wherein the steps of the method include obtaining a blood sample from the subject; contacting the blood sample with an effective amount of tissue factor under conditions conducive to coagulating blood; and detecting the amount of thrombin produced in the blood sample at a pre-determined time point.
REFERENCES:
patent: 6403381 (2002-06-01), Mann et al.
patent: 6645768 (2003-11-01), Tejidor et al.
patent: 2003/0064414 (2003-04-01), Benecky et al.
patent: WO 02/079375 (2002-10-01), None
Brummel Kathleen
Mann Kenneth G.
Conlin David G.
Edwards Angell Palmer & & Dodge LLP
Gitomer Ralph
Kim Dwight D.
The University of Vermont and State Agriculture College
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