Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Oxytocin; vasopressin; related peptides
Patent
1985-10-23
1988-05-03
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Oxytocin; vasopressin; related peptides
530328, 530329, 514807, A61K 3700, C07C10352
Patent
active
047421541
ABSTRACT:
Peptides whose structures resemble those of vasopressin antagonists but have both a carboxamido amino acid unit and a basic amino acid unit in the side chain have good antagonist activity. A species of the invention is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-glutamine-9-desglycine]-vasopressi n.
REFERENCES:
patent: 4469679 (1984-09-01), Huffman et al.
patent: 4481193 (1984-11-01), Ali et al.
patent: 4481194 (1984-11-01), Ali et al.
M. Manning et al., Nature, 308 652 (1984).
Bryan William M.
Huffman William F.
Moore Michael L.
Hall Linda E.
Lourie Alan D.
Nutter Nathan M.
Phillips Delbert R.
SmithKline Beckman Corporation
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