Glial mitogenic factors, their preparation and use

Details Glial mitogenic factors, their preparation and use Glial mitogenic factors, their preparation and use

2011-06-28

2011-06-28

Stucker, Jeffrey (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S399000, C514S007600, C514S009600, C514S017400, C514S017700, C514S021300

Reexamination Certificate

active

07968678

ABSTRACT:
Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.

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