Glial cell line-derived neurotrophic factor antibody

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 72, 435 74, 435 7021, 43524027, 436 63, 436501, 5303871, 5303879, 5303881, 5303882, 53038885, 5303892, 530399, 530809, 530839, 935 89, 935 95, 935108, 935110, C07K 1622, C12P 2108, C12N 512, G01N 3353

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059357959

ABSTRACT:
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. Antibodies to GDNF are disclosed, as well as methods for identifying members of the GDNF family of neurotrophic factors.

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