Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1995-05-26
2000-07-25
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
435 581, 435 701, 435 703, 435 704, 435 711, 435 712, 530413, 530417, 530416, C07K 14475, C07K 1448
Patent
active
060938021
ABSTRACT:
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
REFERENCES:
patent: 4518526 (1985-05-01), Olson
patent: 4742003 (1988-05-01), Derynck et al.
patent: 4886747 (1989-12-01), Derynck et al.
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 5011472 (1991-04-01), Aebischer et al.
patent: 5017735 (1991-05-01), Fellmann et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5158881 (1992-10-01), Aebischer et al.
patent: 5215969 (1993-06-01), Springer et al.
patent: 5250414 (1993-10-01), Schwab et al.
patent: 5276145 (1994-01-01), Bottenstein
patent: 5283187 (1994-02-01), Aebischer et al.
patent: 5284761 (1994-02-01), Aebischer et al.
Aebischer et al. (1991), `Long-Term Cross-Species Brain Transplantation of a Polymer-Encapsulated Dopamine-Secreting Cell Line`, Exper. Neurol., 111:269-275.
Beltz et al. (1983), `Isolation of Multigene Families and Determination of Homologies by Filter Hybridization Methods`, Methods in Enzymology, 100:266-285.
Bohn et al. (1989), The Development of Mesencephalic Dopaminergic Neurons in Vitro is Affected by Neurotrophic Activities Derived from Neural Cell Lines, Soc. Neurosci. Abs., 15:277.
Collins (1978), `Axon Initiation by Ciliary Neurons in Culture`, Develop. Biol., 65:50-57.
Dayhoff, in Atlas of Protein Sequence and Structure vol. 5, p. 124 (1972), National Biochemical Research Foundation, Washington, D.C.
Friedman et al. (1987), `The toxicity of MPTP to dopamine neurons in culture is reduced at high concentrations`, Neuroscience Letters, 79:65-72.
Heikkila et al. (1984), `Behavioral Properties of GBR 12909, GBR 13069 and GBR 13098: Specific Inhibitors of Dopamine Uptake`, Euro J. Pharmacol., 103:241-248.
Hofer and Barde (1988), `Brain-derived neurotrophic factor prevents neuronal death in vivo`, Nature, 331:261.
Kozak (1987), `An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs`, Nucleic Acids Res., 15:125-48.
Leibrock et al. (1989), `Molecular cloning and expression of brain-derived neurotrophic factor`, Nature, 341:149-152.
Lin et al. (1989), `Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)`, Science, 246:1023.
Lo et al. (1990), `A Straiatal-Derived Neurotrophic Factor (NTF): Relationship to Parkinson's Disease (PD)`, Soc. Neurosci. Abstr., 16:809.
Maisonpierre et al. (1990), `Neurotrophic-3: A Neurotrophic Factor Related to NGF and BDNF`, Science, 247:1446-1451.
Manthorpe et al. (1986), An Automated Colorimetric Microassay for Neuronotrophic Factors, Develop. Brain Res., 25:191-198.
Nijima et al. (1990), `Enhanced survival of cultured dopamine neurons by treatment with soluble extracts from chemically deafferentiated striatum of adult rat brain`, Brain Res., 528:151-154.
Schubert et al. (1974), `Clonal cell lines from the rat central nervous system`, Nature, 249:224-227.
Thoenen and Edgar (1985), `Neurotrophic Factors`, Science, 229:238-242.
Tresco et al. (1992), `Polymer Encapsulated Neurotransmitter Secreting Cells`, ASAIO, 38:17-23.
Varon and Bunge (1979), `Trophic Mechanisms in the Peripheral Nervous System`, Ann. Rev. Neuroscience, 1:327-361.
Williams, et al. (1986), `Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection`, Proc. Natl. Acad. Sci. USA, 83:9231.
Winn et al. (1991), `Behavioral Recovery following Intrastriatal Implantation of Microencapsulated PC12 Cells`, Exper. Neurol., 113:322-329.
Wurm, Florian M. (1990), `Integration, Amplification and Stability of Plasmid Sequences in CHO Cell Cultures`, Biologicals, 18:159-164.
Bakhit et al. (1991) Brain Res. 560:76.
Burt (1992) Biochem. and Biohphys. Res. Comm. 184:590.
Creighton et al. (1984) Proteins: Structure & Molecular Properties (Freeman Co., New York) 39-41.
Edgar et al. (1979) Experimental Cell Res. 121:353.
Engele et al. (1989) Soc. Neuroscience Abstract 15:277.
Gentry et al. (1989) Growth Inhibitory and Cytotoxic Polypeptides 143:154.
Guenther et al. (1985) EMBO J. 4:1963.
Houlgatte et al. (1989) J. Neuroscience Res. 24:143.
Ito et al. (1986) Brain Res. 374:335.
Kaisho et al. (1990) Febs Letters 266:187.
Kim et al. (1991) The International J. Biochem. 23:1307.
Kimura et al. (1990) Nature 348:257.
Lin et al. (1993) Science 260:1131.
Lin et al. (1993) Soc. Neuroscience Abstracts 19:651.
Norrgren et al. (1980) Exp. Cell Res. 130:31.
Purchio et al. (1987) Gene 60:175.
Selingfreund et al. (1991) Proc. Natl. Acad. Sci. USA 88:3554.
Sofer and Britton (1983) Biotechniques 1:198.
Ullrich et al. (1983) Nature 303:821.
Watson et al. (1987) in Molecular Biology of the Gene, 4th ed., (eds.) Benjamin Cummings Publishing Co. Amenlo Park, CA, p. 607.
Bektesh Susan
Collins Franklin D.
Doherty Daniel H.
Lile Jack
Lin Leu-Fen H.
Amgen Inc.
Curry Daniel R.
Levy Ron K.
Odre Steven M.
Schain Howard E.
LandOfFree
Glial cell line-derived neurotrophic factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glial cell line-derived neurotrophic factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glial cell line-derived neurotrophic factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1337378