Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-01-24
1997-04-22
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
4241851, 435 691, 435 711, 4351721, 4352523, 43525411, 530350, A61K 3818
Patent
active
056229283
ABSTRACT:
Disclosed are (1) a novel glia activating factor which has glial cell growth promoting activity; (2) a glia activating factor containing a polypeptide; (3) a DNA coding for a glia activating factor; (4) a host transformed with a vector containing the DNA and (5) a method for producing the above glia activating factor which comprises cultivating the transformant described in a medium, accumulating the glia activating factor in a culture broth, and collecting the resulting glia activating factor.
REFERENCES:
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Giulian et al. , article "Brain peptides and Glial Growth: II. Identification of Cells that Secrete Glial-Promoting Factors", The Journal of Cell Biology , vol. 102, pp. 812-829, March 1986.
Giulian et al., article "Brain peptides and Glial Growth: I. Glia-Promoting Factors as Regulators of Gligoeneis in Developing and Injured Nervous System", The Journal of Cell Biology, vol. 102, pp. 803-811, Mar. 1986.
Chemical Abstracts, vol. 98, No. 15, Apr. 11, 1983, Columbus, Ohio, US; Abstract No. 123664a, Nister M. et al: "A platelet-derived growth factor analog produced by a human clonal glioma cell line", p. 445; column L.
Chemical Abstracts, vol. 96, No. 1, Jan. 4, 1982, Columbus, Ohio, US; Abstract No. 4542H, Kato, Taiji et al: "Glial cell growth-promoting factor in astrocytoma C6 cell extracts", p. 421; column L.
Chemical Abstracts, vol. 110, No. 11, Mar. 13, 1989, Columbus, Ohio, US; Abstract No. 89388T, Guilan, Dana et al: "Secreted peptides as regulators of neuron-glia and glia interactions in the developing nervous system " p.162; column L.
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Kondo Tatsuya
Kurokawa Tsutomu
Naruo Ken-ichi
Seko Chisako
Conlin David G.
Lowen Cara Z.
Neuner George W.
Nucker Christine M.
Scheiner Laurie
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