Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-11-17
1996-04-30
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 235, 435 711, 4351721, 4352401, 4352523, 43525411, C12N 1512, C12N 121, C12N 510, C12P 2106
Patent
active
055124607
ABSTRACT:
Disclosed are (1) a novel glia activating factor which has glial cell growth promoting activity; (2) a glia activating factor containing a polypeptide represented by SEQ ID NO: 1 or a mutein thereof having activity of the factor; (3) a DNA containing a polynucleotide coding for a glia activating factor represented by SEQ ID NO: 10; (4) a host transformed with a vector containing the DNA described in (3); and (5) a method for producing the above glia activating factor which comprises cultivating the transformant described in (4) in a medium accumulating the glia activating factor in a culture broth, and collecting the resulting glia activating factor.
REFERENCES:
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Giulian et al., article "Brain peptides and Glial Growth: I. Glia-Promoting Factors as Regulators of Gligoeneis in the Developing and Injured Nervous System", The Journal of Cell Biology, vol. 102, pp. 803-811, Mar. 1986.
Chemical Abstracts, vol. 98, No. 15, Apr. 11, 1983, Columbus, Ohio, US; Abstract No. 123664A, Nister M. et al: "A platelet-derived growth factor analog produced by a human clonal glioma cell line", p. 445; column L.
Chemical Abstracts, vol. 96, No. 1, Jan. 4, 1982, Columbus, Ohio, US; Abstract No. 4542H, Kato, Taiji et al.: "Glial cell growth-promoting factor in astrocytoma C6 cell extracts", p. 421; column L.
Chemical Abstracts, vol. 110, No. 11, Mar. 13, 1989, Columbus, Ohio, US; Abstract No. 89388T, Guilan, Dana et al.: "Secreted peptides as regulators of neuron-glia and glia--glia interactions in the developing nervous system" p. 162; column L.
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Kondo Tatsuya
Kurokawa Tsutomu
Nauro Ken-ichi
Seko Chisako
Conlin David G.
Lowen Cara Z.
Mosher Mary E.
Neuner George W.
Scheiner Laurie
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