Glaucoma treatment

Details Glaucoma treatment Glaucoma treatment

1990-03-02

1991-07-30

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

5142362, 514400, 514538, 514540, 514542, 514601, 514605, 514613, 514617, 514625, 514913, A61K 3700, A61K 31535, A61K 31415, A61K 3124

Patent

active

050360515

ABSTRACT:
A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## where A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is Ch.sub.2 ; R.sub.1 is loweralkyl, cycloalkyl methyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-bezyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkyamino.

REFERENCES:
patent: 4442089 (1984-04-01), Horowitz
patent: 4587258 (1986-05-01), Gold et al.
patent: 4845079 (1989-07-01), Luly et al.

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