Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-03-02
1991-10-22
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 18, 514626, A61K 3700, A61K 3116
Patent
active
050595890
ABSTRACT:
A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, 1-bezyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)loweralkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is substituted hydroxyalkylamino.
REFERENCES:
patent: 4442089 (1984-04-01), Horowitz
patent: 4587258 (1986-05-01), Gold et al.
Plattner et al., Biochem. Biophys. Res. Commun. 139, 982 (1986).
Crowley Steven R.
Plattner Jacob J.
Stein Herman H.
Abbott Laboratories
Crowley Steven R.
Fay Zohreh A.
Waddell Frederick E.
Weinstock Steven F.
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