Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2006-12-12
2006-12-12
Helms, Larry R. (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S277100, C424S094100, C435S325000, C435S320100, C435S184000, C435S091100, C435S069200, C536S023200
Reexamination Certificate
active
07147855
ABSTRACT:
The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical compositions thereof. The present invention also provides isolated GIP90/130 nucleic acid sequences, expression vectors comprising the nucleic acid sequences, and host cells transfected with the expression vectors. The invention further provides methods for detecting the GIP90/130 polypeptides or nucleic acid sequences, methods for inhibiting interactions between GPBP and GIP90/130 polypeptides, between pol k76 and GIP90/130 polypeptides or aggregation of GIP90/130 polypeptides, and methods for treating patients with autoimmune disorders or cancer.
REFERENCES:
patent: WO 00/50607 (2000-08-01), None
patent: WO 00/73801 (2000-12-01), None
patent: WO 02/46378 (2002-06-01), None
patent: WO 02/061430 (2002-08-01), None
See, e.g., Ngo, et al, The Protein Folding Problem and tertiary Structure Prediction, 1994, Merz, et al. (ed.), Birkhauser, Boston, MA, pp. 492-495).
Copy of search report dated Aug. 12, 2003 for counterpart PCT application No. PCT/EP02/13802.
Genbank Entry Accession No. U53445.
Genseq Entry Accession No. AAG03283.
Genseq Entry Accession No. AAB58157.
Raya et al. (Apr. 30, 1999) “Characterization of a Novel Type of Serine/Threonine Kinase that Specifically Phosphorylates the Human Goodpasture Antigen”Journal of Biological Chemistry274(18): 12642-12649.
Revert et al. (Jun. 2, 1995) “Phosphorylation of the Goodpasture Antigen by Type A Protein Kinases”Journal of Biological Chemistry270(22): 13254-13261.
Raya et al. (Dec. 22, 2000) “Goodpasture Antigen-Binding Protein, the Kinase that Phosphorylates the Goodpasture Antigen, is an Alternatively Spliced Variant Implicated in Autoimmune Pathogenesis”Journal of Biological Chemistry275(51):40392-40399.
EMBL Entry Accession No. AF329092.
Genbank Entry Accession No. BC027860.
Mok, et al., (1994), Gynecol. Oncol., vol. 52(2), pp. 247-252.
Genomic DNA Entry Accession No. NT—030634 for exon I.
Genomic DNA Entry Accession No. NT—033050 for the rest of the exons.
Genbank Entry Accession No. BAC00851.
Genbank Entry Accession No. BAA86589.
Nagano, et al., Nature Cell Biology, (2002), Jul., vol. 4(7), pp. 495-501.
Revert-Ros Francisco
Saus Juan
Baskar Padma
Helms Larry R.
McDonnell Boehnen & Hulbert & Berghoff LLP
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